Don't engage right away, see if there's a portal near him. If so, knock him away from it to prevent fleeing and healing. If your ult is up, stun him to prevent another portal and to protect yourself from Broadside.
Dredge Anchor comes from Makoa's left hand; when engaging him, try to use map walls/objects for cover on his left side to waste his Anchor. Never use Kinetic Burst/Shoulder Bash him unless you know his Anchor is down, as he can pull you along.
Cripple hurts Yagorath's Accelerate. Aside from that, Yagorath is favored in other aspects. 1) Sha doesn't have the best tank-burn compared to other DPS. 2) He is squishy. 3) Primal Vision and acid pools can keep track of his stealth.