Crowd control reduction or immunity is critical against Atlas, especially if you are a tank or support. This will make you less vulnerable to his Rewind effect, and reduce the time you are trapped by his ultimate.

When going for Io, be wary of Luna, as her stun will track you and knock you down if you are airborne. Luna is otherwise an easy target to poke down if you don't have a better target, either killing her or forcing Io to pull her back to safety.

Androxus's high mobility and hitscan weapon give him significant advantages. You can try to lure him to a confined space to limit his mobility and make your weapon easier to hit with, and use Dead Zone to restrict his ability to heal.

Unless he's using the Half Shell talent and/or the Barrier Reef loadout card, Makoa will often be vulnerable to weapon shots, especially during his ultimate. Using the Blastflower talent will help you to shred his large health pool.