Unless he's using the Half Shell talent and/or the Barrier Reef loadout card, Makoa will often be vulnerable to weapon shots, especially during his ultimate. Using the Blastflower talent will help you to shred his large health pool.

Io has very high healing output between her Moonlight and Luna. Make sure you use Dead Zone to help you close out kills on damaged enemies, or Io may be able to save them.

Keep your distance from Torvald! His damage is worth being wary of, and his Nullify ability will prevent you from activating your skills to escape.

Torvald has no way to prevent damage being dealt to him besides his personal shield. If you choose the Blastflower talent and buy Wrecker, he will be forced to either retreat to cover or quickly die.