Use Resonance against a Tyra. Her Fire Bomb will kill any clones you put on point anyway, so you might as well take Resonance so that every time the fire kills your clones, they explode and deal damage to the enemy frontlines.
Agony is great against Terminus. He deals a lot of damage to your tanks, and it can be hard for some tanks to escape him. Stunning him gives your frontlines a chance to get away, and makes him vulnerable. Stunning him can also cancel his Siphon.