Ash's Shoulder Bash ends upon hitting a target. Try to block off her most convenient escape path when she reaches low health, trading 800 health for a basically guaranteed kill.
Unless your Champion's basic attack is hitscan, like Viktor or Tyra, you'll be hard-pressed to hit Androxus while he's airborne. Wait for him to land, if you can.
This matchup is one of the harder ones for Skye. Try to move in after Jenos uses Void Grip. Skye's strength is mobility, and Void Grip takes that strength away from her (Albeit temporarily).