Talus relies on his Rune of Travel to save himself from bad engagements. Look out for them and check stealth grass as he can try to use them as cover for his rune.
Talus can do a lot of damage in a 1 vs 1 but his health relatively low. Travel is groups of two or more if possible and necessary. You can force him to use his Rune of Travel early and cut unnecessary damage from you or your team by focusing him.
Skye's Ultimate can be devastating to your team's collective health. But you can be as close to it as you want as long as you break line of sight. If Skye doesn't put the Ult on the Payload, you can you said payload to block ALL Damage from it.
DO NOT BYE ILLUMINATE. She will still see you first. Skye's main strength is she has a lot of burst damage. Pick up Haven to survive her bust easier (and help with other champions).
If Androxus tries to flank and kill you, be careful where you shoot. If he uses Reversal, you can try to shoot behind him and use splash damage to kill him since reversal only takes damage from the front and Androxus can't shoot while in Reversal.