After slowing skye, you can kill her easily, make sure, when she tries to turn invisible shoot a projectile to the ground, the blast will kill her. I recomend Catalyst legandary!
Utilize her deployables to your advantage by running Brawl in your loadout. If she is running Treacherous, never use Shoulderbash before she deploys Warder's Field. Focus on killing her healer for an easier matchup.