Tip overview

Bulldozer will be your best friend. Anything that cripples as she get low on HP is almost necessary. CC reduction is also gonna be a big difference. Take out her foxes first enemies second, her healing is very solid so focus on her not the tank.

If you find IO while Luna is still active, instead of targeting Luna to get her down go for IO. When she dies, her fox dies. This is similar to Barik with his deployable and Inara with warder's field. They all are removed from the field after death

Io looks not dangerous but damage she and Luna deal is high. If you want to take her down, catch her staying far from Luna. If Io is smart and uses Luna for own protection summon your ally to take them two down. You can also buy resilience for Luna.

most champions will have a hard time dealing with Io and Luna together, so don't engage them together instead try to single out Luna while Io isn't around, so when it comes time to kill Io she can't stun you or body block with Luna.

no champ can defeat Io with luna