Always reload before using [Evil Mojo], as you only get a short amount of time to kill off everyone affected. It is also a good idea to save it until multiple allies are nearby, if at all possible.
Try to wait for Tyra to use her Fire Bomb on somebody else. If she is unprotected use Acceleration to get close to her and kill her. She can hardly do anything against you without her Fire Bomb.
Ruckus is a good champion to use "Reversal" on; it might even outright kill him when he's using his ultimate.
Try to get in front of him quickly when he's already firing on your teammates, but be sure to have an equally fast escape!
Use agility and then run circles around her the only way you will lose this is if she knows you are coming from a distance. Also your ultimate destroys her.