When Io deploys Luna, you can use Broadside to deal big damage or force Io to move her, leaving Luna further from the middle of the field and on a cooldown. With Bulldozer, you can take Luna down with a single rclick, keeping it from the point.
Remember to get rid of enemy deployables especially Barik's turrets and even more when he has the turret legendary card. They are not something to be ignored because when they are you don't realize when you are getting damaged
Vatu needs to come close to your teammates to deal signifant damage, so if you are playing cripple always keep an eye on them and cripple him as soon as he dives