A Grohk with Maelstrom sacrifices healing for large amounts os AoE damage and self-healing, allowing him to solo duos and even trios. Grab Cauterize to shut him down instantly.
With the Aerial Assault legendary card, dodging Dragon Punch can be made trivial. Waiting for him to close in to a medium distance then using two charges to jump up and saving one for if he swerves back will save you most times.
Be ready for Jenos' ult. You have plenty of time to move out of the way as long as you are ready for the tell. Also, consider buying Resilience to shorten down the void grip if either they have it's legendary, or if you have no mobility.
If you can land a Pyre Strike on Talus when he's approaching half health, you can keep him from manually returning to his Rune of Travel and give you and your team time to finish him off.