If an enemy Skye uses her Smokescreen to escape nearby, you can use your abilities to trap the Skye by dropping your Warder's Field and Impasse in the nearest available exits. She can then be quickly bursted down in a 1v1 situation.
In Pursuit is highly effective against her. One or two shots are all it takes to let In Pursuit finish her off. Side note: She might heal while you are using In Pursuit should she have Artful Dodger, Patch Up, and/or Savagery.