Talus is a champion with high burst damage and excels in a 1v1 against any unsuspecting enemy backlines. However he is vulnerable to any types of CC whether it is stuns, slows or cripples. If you are hit by these, then you're in deep trouble.
Contrary to what you may see here, setting your rune in the enemy's line of sight can work to your advantage if you have the Inner Strength legendary. The enemy expects you to be weak and on cooldowns when you return to your rune.