Placing your Dead Zone on Grohks Totem completely counters his healing potential for a few seconds.

Try to re-roll Retribution as often as you can until you can see Skye. Then you have an incredible advantage and should dominate her easily.

You can detonate his ultimate (earlier) by pushing the F key (or whatever you bound Mal'Dambas ultimate to) again!

When fighting against her, the "Deep Roots" legendary is mandatory. She will reduce your healing anyway, and by rooting her you can render mobility potential unusable for a few seconds