Don't try and flank Jenos, he will use stellar wind, and if you're not using agony the damage of rend soul wont be enough to kill the jenos when his out of your LOS (line of sight)
when skye decloacks throw at her 1-2 orbs, go into shadow travel, if she is still declocaked throw some more orbs and wait until she goes invis and detonate the soul charges so you can see where she is at and finish her.
Do not hold the fire button when playing as Fernando. Your weapon deals damage over time after each hit.
Tapfire instead, so you can get value out of the DoT and refill your ammo in between shots.