This matchup is one of the harder ones for Skye. Try to move in after Jenos uses Void Grip. Skye's strength is mobility, and Void Grip takes that strength away from her (Albeit temporarily).
Don't engage right away, see if there's a portal near him. If so, knock him away from it to prevent fleeing and healing. If your ult is up, stun him to prevent another portal and to protect yourself from Broadside.
Use the totem legendary to give your green circle cc immunity. Deploy to heal and hop inside when the grumpy bomb is near you. Grumpy bomb does little damage so the totem essentially negates it.