Buy "illuminate" from the item shop (at least to level 2 if your struggling against her), she will never think twice to go for you again as you will see her coming from a mile away!
DO NOT buy illuminate, it won't stop her from flanking you, instead, buy haven. Makes it so that it takes more than one one magazine to kill you adding reload time where she is vulnerable. Burst her down so she can't hit as man shots.
Skye is extremely squisy. Try to stay as sneaky as you can. Also avoid AOE champions as much as you can because they can still hit you even if they are not aiming at you.