Tip overview

If Skye is still present after she tosses "Timebomb", you can "Reversal" its damage by aiming the "Reversal" channel at Skye herself during the detonation, all dmg will be absorbed and you can then fire 2400 dmg at any target of your choosing.

Using reversal when skye starts shooting, followed by nether steps and try not to lose track of the enemy(while shooting ofcourse)