If Tyra is using the First Blood legendary card and/or liferip, you can use cauterize to counter the healing.

Tyra has almost no escape skill. Caught once, she will be an easy target

Tyra's Fire bomb is unaffected by Heaven or Blast shields. Be sure to avoid it at all costs unless absolutely necessary; Some healers such as Ying or Mal'Damba can prolong a frontlines' life in unavoidable situations.