If Grohk is using totemic ward, he does have cc immunity against your ult and rewinds, but you can just 2 tap his base totem without buying bulldozer. If Grohk is using maelstrom, your stasis field eats his shock pulse, preventing the spam.

Totemic Ward's cc immunity prevents heavy blade's slow, and he can ghost walk to avoid heavy combat's burst. His ult slows the enemy, therefore his ult counters your ult.

Overall, Skye counters Io. Skye does too much damage to Io and Io doesn't have a good escape or anything that can cleanse Skye's poison. Though when Skye tries to ult the point, you can ult as well to immune the damage. That's about it though.

You have too much health and sustain for Lian to burst through. Just run into her and start firing, she'll be dead soon.