Jenos should be higher in weakness list his relativity ability with his atral mark at max can out heal skye's base damage (unless she poison darts you then your screwed), and his void ability destroys her mobility allowing people to hit her.
Tiberius deals 650 damage every .7 seconds, and .49 seconds during combat trance. That's a burst of 1300 every second for 4 seconds. Your best bet is to use someone like Lian to outburst him, or someone who can avoid his burst.