When you want to engage Tyra, be sure to attackher on the back and become invisible again juste after your first damage in order to avoid being marked, this strategy is risky but often pays off.
He may attempt to use Reversal on your Stickybombs, be smart and don't aim directlly at him. He can still be hit by behind and the sides, a sticky bomb over him can deal significant damage, while he's unable to react.