Make sure you keep track of her ultimate. It can devastate your team if it is paired with another ult.

Guess what you can fly up. This will cause bucks shotgun shells to spread and reduce the overall damage to you.

You can reversal his Hit Scan if you stay in front of him. Sending his damage back at him.

If you hit your alt fire on her you should focus her down because she will lose a lot of her mobility and be an easy kill.