Strix's stealth can make him harder to track, so toss your Sensor Drones out where you expect him to be and reveal him to your team. If you run the Booby Trap talent, the explosion of your drones can disrupt his aim or throw him off of high ground.
Unless recently killed, you can usually count on Luna to be somewhere near the fight, and for Io to be standing near her. Use your Shock Pulse on Luna for a free bounce between them. This might not apply if Io is using the Sacrifice talent.
If you have several totems down and Willo hits you with Dead Zone, you can use your Ghost Walk to briefly cleanse the effect and continue to heal yourself.
With the Treacherous Ground talent, you can prevent Grohk from using his Ghost Walk. With moderate levels of anti-healing, you can potentially kill him even through the healing of his totems.
Yagorath is the largest target in the game. You can shoot your Fire Spit and let it hit her directly for a significant damage boost. If you combine it with the Fusillade talent, your rockets will be able to overpower her natural damage reduction.