Create a wall between you and the time bomb to complete negate it

If an enemy Skye uses her Smokescreen to escape nearby, you can use your abilities to trap the Skye by dropping your Warder's Field and Impasse in the nearest available exits. She can then be quickly bursted down in a 1v1 situation.

If Skye attempts to use her ult next to you, quickly bring up your wall (impasse) to shield yourself. This might not always work, but bringing up your wall + earthen guard can make sure you survive and stay on point. Placement is key!

Focus on Inara last, aim for everyone else first. When needed, poison her and get a couple hits in, but make sure to move around so she has a hard time hitting you because her shooting time is slow.