Skye has the highest DPS in the game when at close quarters. Sometimes it's better to turn around and block her shots with your shield or Charge away. Judge from where the most damage is coming from.

It's very important to remember that's Skye's ult breaks shields. If it gets dropped near you, lower your shield and run for cover.

When is dealing with someone else use poison arrows and then keep shooting (dont forget legendary card fot poison damage boost). Now thats a definite kill.