Willo's Dead Zone ability is very effective against 'local healing' this includes grovers healing, Grohk's totem and similar things. Dead zone will prevent deployables from being effective and will force champions like Grover to move out of the zone.

A Lian with good reaction time can use her ultimate to block Androxus' ultimate and reversal. A good Androxus will nether step away after reversal and your ultimate will almost definitely kill an Androxus mid-ult if hes already been damaged.

Viktor's ultimate is reliant on him having direct vision of you so moving out of sight behind a corner or using opaque deployables(such as Inara's wall) will prevent him from selecting your location.

Unlike most front liners and supports grover has very good long range pressure. He can use his bonus damage scaling legendary to harass enemy front liners from long range or long range enemies from the objective easily.